Abstract: Objective To examine two-week morbidity rate of diseases and its major influential factors among the residents aged 15 years and above in Shandong province.Methods Totally 28788 permanent residents ≥15 years old from 12010 families were selected randomly by means of stratified-cluster sampling and surveyed with a standardized questionnaire.General descriptive analysis,single factor analysis and logistic regression analysis were used in data analyses.Results The overall two-week morbidity rate was 25.5% for all the residents(24.0% for the men,26.9% for the women,24.5% for urban residents,27.7% for rural residents,47.0% for the residents aged 60 years and above,50.7% for the widowed,38.2% for the residents with the education of primary school and below,50.0% for the retired,and 23.5% for the residents with low income,respectively).Main influential factors of the two-week morbidity rate were age,education level and employment status among the residents based on the results of logistic regression.The diseases with top five morbidity rate were hypertension,upper respiratory tract infection,diabetes,arthritis,and acute or chronic gastroenteritis.Conclusion At older age,with low education,being retired or unemployment are important risk factors for increased two-week prevalence of diseases among the residents in Shandong province.