Abstract: Objective To investigate the effect of vitamin E supplementation on cardio-cerebrovascular disease events(stroke,myocardial infarction,and transient ischemic attack)and to provide a reference for the prevention and treatment of cardio-cerebrovascular diseases.Methods The published literature from 1980 through 2014 on randomized controlled trials(RCTs)on the relationship between vitamin E supplement and cardio-cerebrovascular diseases were searched through Pubmed,EMBASE,OVID,Healthstar,Cochrane database,Google Scholar,Science Citation Index,Wanfang database,China National Knowledge Infrastructure,Chinese Biomedical Data-Base,and VIP Chinese Science and Technology Periodical Database.The data were analyzed with meta-analysis using Revman software version 5.1.Results Totally 13 RCTs were involved in the analysis,including 62871 vitamin E intervention cases and 62837 placebo controls.The meta-analysis showed that vitamin E supplementation had no effect on the incidence of cardiovascular disease events(relative risk(RR)=0.99,95% confidence interval(95% CI)=0.96-1.02),stroke(RR=1.03,95% CI=0.96-1.10),myocardial infarction(RR=0.99,95% CI=0.93-1.04),and transient ischemic attacks(RR=0.94,95% CI=0.82-1.09).Subgroup analysis indicated that gender,follow-up duration,whether with other interventions,and doses of vitamin E had no confounding effect on the occurrence of cardio-cerebrovascular disease in the RCTs(all P>0.05).Conclusion Vitamin E might have no significant influence on cardio-cerebrovascular disease events.