Predictive value of obesity and metabolism indexes for hyperuricemia among rural adult Yi residents in Liangshan region
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摘要: 目的 分析四川省凉山彝族农民肥胖及代谢相关指标对高尿酸血症(HUA)的预测价值,为HUA的防治提供参考依据。方法 2014年6-8日采用分层整群随机抽样方法对在凉山彝族自治州农村地区进行分层整群随机抽样,抽取的972名 ≥18周岁以上常住居民972人,调查内容包括进行问卷调查、体格检查和血实验室检测;采用Spearman相关分析法分析肥胖及代谢相关指标与HUA之间的关系,并采用ROC曲线确定HUA的最佳预测值。结果 凉山彝族自治州农村居民HUA患病率为18.7%,标化患病率为22.0%,男性和女性HUA患病率分别为27.2%和11.3%,标化患病率分别为30.4%和12.3%;不同性别彝族农村居民HUA患病率比较,差异有统计学意义(χ2=105.429,P=0.001);Spearman相关分析结果显示,男性体质指数(BMI)、腰围、臀围、腰臀比、腰高比、甘油三酯(TG)与血尿酸(SUA)均呈正相关(均P<0.01),高密度脂蛋白胆固醇(HDL-C)与SUA呈负相关(r=-0.132,P=0.005);女性BMI、腰围、臀围、腰臀比、腰高比、总胆固醇(TC)、TG、低密度脂蛋白胆固醇(LDL-C)与SUA均呈正相关(均P<0.01),HDL-C与SUA呈负相关(r=-0.115,P=0.009);HUA诊断ROC曲线显示,男性BMI的AUCROC最大为0.635(切点为23.0 kg/m2),女性臀围的AUCROC最大为0.605(切点为87.50 cm)。结论 凉山彝族农村居民的HUA患病率较高, BMI、腰围、臀围、腰臀比、腰高比、TC、TG、LDL-C、HDL-C等肥胖及代谢相关指标对HUA有一定预测价值。
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关键词:
- 高尿酸血症(HUA) /
- 肥胖及代谢相关指标 /
- 预测价值 /
- 彝族农村居民
Abstract: Objective To explore predictive value of obesity and relevant metabolism indexes for hyperuricemia(HUA)among rural Yi residents in Liangshan Yi Autonomous Prefecture(Liangshan)of Sichuan province.Methods Stratified random cluster samp1ing was adopted to select 972 permanent residents aged ≥18 years in Liangshan for a cross-sectional study with questionnaire survey,physical examination,and laboratory detection.Spearman correlation was used to analyze the relationship between HUA and obesity indexes and receiver operating characteristic(ROC)curve was used to determine the best predictable value of HUA with maximum Gordon's index as the best cut-off point.Results Among the 972 participants(452 males and 520 females),the HUA prevalence rate was 18.7%(27.2%for the males and 11.3%for the females)and the standardized prevalence rate was 22.0%(30.4%for the males and 12.31%for the females);there was a significant gender difference in HUA prevalence rate among the participants(χ2=105.429,P=0.001).There were significant age-differences in body mass index(BMI),waist circumference(WC),hip circumference(HC),waist-to-hip ratio(WHR),waist-to-height ratio(WHTR),total cholesterol(TC),and low density lipoprotein cholesterol(LDL-C)in both the male and female participants(all P<0.05) and a significant age-difference in serum uric acid(SUA)in the male participants (P<0.05).Spearman correlation analyses showed that SUA was positively correlated with BMI,WC,HC,WHR,WHTR,and triglyceride(TG)(all P<0.01)but reversely correlated with high density lipoprotein cholesterol(HDL-C)(r=-0.132,P=0.005)among the male participants;whereas among the female participants,SUA was positively correlated with BMI,WC,HC,WHR,WHTR,TC,triglyceride(TG),and LDL-C(all P<0.01)but reversely correlated with HDL-C (r=-0.115,P=0.009).The highest area under the ROC curve of BMI for HUA diagnosis was 0.635,with a cut-point of 23.0 kg/m2,for the male participants and that of HC for HUA diagnosis was 0.605,with a cut-point of 87.50 cm for the female participants.Conclusion The prevalences of HUA and obesity are high and obesity and relevant metabolic indexes are of predicative significance for HUA among rural adult Yi residents in Liangshan region. -
[1] Kim SY,Guevara JP,Kim KM,et al.Hyperuricemia and coronary heart disease:a systematic review and meta-analysis[J].Arthritis Care and Research,2010,62(2):170-180. [2] Bhole V,Choi JWJ,Kim SW,et al.Serum uric acid levels and the risk of type 2 diabetes:a prospective study[J].The American Journal of Medicine,2010,123(10):957-961. [3] Grayson PC,Kim SY,LaValley M,et al.Hyperuricemia and incident hypertension:a systematic review and meta-analysis[J].Arthritis Care and Research,2011,63(1):102-110. [4] Krishnan E,Pandya BJ,Chung L,et al.Hyperuricemia in young adults and risk of insulin resistance,prediabetes,and diabetes:a 15-year follow-up study[J].American Journal of Epidemiology,2012,176(2):108-116. [5] Aekplakorn W,Pakpeankitwatana V,Lee CMY,et al.Abdominal obesity and coronary heart disease in Thai men[J].Obesity,2007,15(4):1036-1042. [6] 蒋瓅,陈雪婉,郑瑞丹,等.腰臀比为非酒精性单纯性脂肪肝最有效的预测指标[J].中华肝脏病杂志,2010,18(11):859-861. [7] 胡晓抒,郭志荣,武鸣,等.体重指数、腰围与代谢性健康风险的关系[J].中华流行病学杂志,2005,26(12):967-970. [8] 徐涛,李卫,胡泊,等.中国11省市成年人吸烟和被动吸烟情况调查[J].中国慢性病预防与控制,2010,18(3):229-230. [9] 马玉霞,张兵,王惠君,等.饮酒行为对我国9省成年居民高血压患病的影响研究[J].中国慢性病预防与控制,2011,19(1):9-12. [10] Fang J,Alderman MH.Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study,1971-1992.National Health and Nutrition Examination Survey[J].JAMA,2000,283:2404-2410. [12] Liu M,He Y,Jiang B,et al.Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population[J].Int J Endocrinol,2014,2014:754678. [13] 王明军,张金荣,潘玲,等.广西城乡成年人高尿酸血症的流行病学调查[J].暨南大学学报:自然科学与医学版,2014,35(3):305-309. [14] Hsieh SD,Yoshinaga H,Muto T.Waist-to-height ratio,a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women[J].International Journal of Obesity,2003,27(5):610-616. [15] 何双涛,刘军.体重指数、腰围与腰臀比对预测高尿酸患病风险的比较[J].中华内科杂志,2014,53(12):976-977. [16] 杨楷,马杰,刘红,等.血尿酸水平与肥胖相关指数的关系[J].微循环学杂志,2008,18(4):66-67. [17] 苗蕾,姚华,徐菲莉,等.脂代谢相关指标和肥胖与血尿酸关系[J].中国公共卫生,2008,24(5):589-591.
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