Interactive effect of genetic and environmental factors on stress response susceptibility
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摘要: 目的 了解遗传与环境因素的交互作用对紧张反应易感性的影响。方法 采用单纯病例研究设计,按照整群随机抽样方法抽取工作紧张测量量表(JSS)得分>90%正常参考值的323名汉族职员进行量表调查,采用Snapshot技术检测GCCR基因4个位点:Rs10482605、Rs41423247、Rs258747、Rs17209237,完成基因-环境交互作用的分析。结果 323名JSS得分较高的脑力作业者中,GCCR基因rs10482605突变型组工作紧张均分为(3.34±0.09)分,野生型组为(3.28±0.07)分,突变型组高于野生型组(P<0.05);GCCR基因rs17209237突变型组在生活事件总刺激项上均分为(49.41±15.60)分,高于野生型组均分(45.76±15.77)分(P<0.05);GCCR基因rs41423247突变型与主观支持有负相乘交互作用(P<0.05,OR=0.237)。结论 GCCR基因可能是紧张反应的遗传易感因素,且与环境因素(社会支持)存在交互作用。Abstract: Objective To investigate the interactive effect of genetic and environmental factors on the susceptibility to stress response among white-collar workers.Methods With stratified cluster sampling,we recruited 323 persons with scores of Job Stress Survey(JSS) higher than 90% of the normal reference value derived from a screening survey on occupational stress with JSS among 3200 Han white-collar workers.All the participants were surveyed with Life Event Scale(LES) and Social Support Rating Scale,and their blood samples were collected and genotyped for 4 locus of glucocorticoid receptor gene(GCCR:Rs10482605,Rs41423247,Rs258747,Rs17209237) with Snapshot technology.Results The participants with the mutation type of GCCR rs10482605 had a significantly higher average JSS score than those with the wild type(3.34±0.09 vs.3.28±0.07,P<0.05);the participants with the mutation type of GCCR rs17209237 had a significantly higher overall LES score than those with the wild type(49.41±15.60 vs.45.76±15.77,P<0.05).The mutated GCCR rs41423247 presented a negative multiplicative interaction to subjective social support(odds ratio=0.237,P<0.05).Conclusion Gene GCCR may be a genetic risk factor for stress response and may have interactive effect with environmental factors on stress response in human.
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Key words:
- stress susceptibility /
- gene /
- environmental factor /
- analysis on interaction
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[1] 兰亚佳,张洋.职业紧张研究现状与展望[J].川北医学院学报,2014,29(1):2-6. [2] Kivimki M,Nyberg ST,Fransson EI,et al.Associations of job strain and lifestyle factors with risk of coronary artery disease:a meta-analysis of individual participant data[J].Can Med Assoc J,2013,185:763-769. [3] 张利新,于浩,罗晓燕,等.职业紧张与工作条件对男性警察糖尿病发病影响前瞻性研究[J].中国公共卫生,2015,31(2):164-168. [4] 连玉龙,刘继文,张晨.工作紧张测量量表JSS信度和结构效度分析[J].中国职业医学,2008,35(5):364-367. [5] 张亚林,杨德森.生活事件量表[M]//汪向东,王希林,马弘.心理卫生评定量表手册.北京:中国心理卫生杂志,1999增刊:101-108. [6] 肖水源.社会支持评定量表的理论基础与研究应用[J].临床精神医学杂志,1994,4(2):98-100. [7] Peng L,Zhang J,Li M,et al.Negative life events and mental health of Chinese medical students:the effect of resilience,personality and social support[J].Psychiatry Res,2012,196:138-141. [8] 梁景煜,陈芳,裴大军,等.高血压冠心病患者心理健康水平与社会支持的相关性研究[J].护理学报,2012,19(5B):1-4. [9] Wust S,Van Rossum Ef,Federenko IS.Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress[J].J Clin Endocrinol Metab,2004,89(2):567-573. [10] 马晓明,岳松,刘乾,等.警察职业紧张状况影响因素分析[J].中国公共卫生,2009,25(6):690-692. [11] Van Winkel R,Stefanis NC,Myin Germeys I.Psychosocial stress and psychosis:a review of the neurobiological mechanisms and the evidence for gene-stress interaction[J].Schizophr Bull,2008.34(6):1095-1105. [12] Lian YL,Xiao J,Wang Q,et al.The relationship between glucocorticoid receptor polymorphisms,stressful life events,social support,and post-traumatic stress disorder[J].BMC Psychiatry,2014,14:232.
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