Abstract: Objective To investigate effects of propofol and isoflurane on serum inflammatory factors in patients with osteoarticular tuberculosis.Methods Totally 229 inpatients undergoing osteoarticular tuberculosis focal cleaning in two hospitals in Shenyang city between June 2012 through June 2015 were divided randomly into a propofol and an isoflurane group and given 3-6μg/mL propofol and 1%-2% isoflurane for anesthetization of the operation,respectively.The patients' serum levels of interleukin-1(IL-1),tumor necrosis factor-α(TNF-α),and intercellular adhesion molecule-1(ICAM-1)were detected before the anesthesia,and at the beginning,12 and 24 hours after the operation.Results The serum levels of IL-1,TNF-α,and ICAM-1 were significantly higher in isoflurane group than those in propofol group at 12 and 24 hours after the operation(all P<0.05).The serum levels of IL-1,TNF-α,and ICAM-1 were significantly increased at the beginning,12 and 24 hours after the operation compared with those before the anesthesia in both groups(all P<0.01).Conclusion Compared to isoflurane,propofol is of greater inhibitive inflammation effect in patients with osteoarticular tuberculosis.