Abstract: Objective To explore the association of pathogenic isolates with febrile respiratory syndrome(FRS)incidents with multiple correspondence analysis and to provide a basis for improving the quality of infectious disease sentinel surveillance.Methods The data on registered FRS cases and laboratory pathogenic detection for the cases in 4 provinces of western China were collected from sentinel surveillance system and analyzed with SAS 9.1.Subgroup analysis and combinations of variables were applied to improve dimension reduction and result.Results The detection rate of pathogens was 15.24%for a total of 3157 specimens of nose/throat swab(39.31%),sputum(31.45%),and blood(16.47%)collected from the FRS cases.There were a lower pathogen detection rate among the FRS cases from provincial hospitals,hospitalized,and with antibiotics use a week before the specimen sampling and a higher rate among those from municipal and county-level hospitals,being attendees of outpatient clinic or emergency department,and without antibiotics use.A lower pathogen detection rate was observed among the FRS cases under the age of 14 years and among the nose/throat swab specimens;whereas the pathogen detection rate was higher for sputum specimens.Conclusion The pathogen detection rate was low among FRS incidents registered by sentinel surveillance in western China,suggesting that the scope of FRS sentinel surveillance should be enlarged and the surveillance in outpatient clinic needs to be improved in provincial hospitals.