Abstract: Objective To investigate the etiological characteristics of hand,foot and mouth disease(HFMD)in Liao-yang city from 2010 through 2013 and to provide scientific evidences for prevention and control of HFMD.Methods Fecal specimens were collected from suspected HFMD patients form 2010 through 2013.All the specimens were tested with reverse transcription PCR(RT-PCR).Results Totally 121,120,242,and 360 specimens were collected per year and the annual virus positive rates of the specimens tested were 87.60%(106),86.67%(104),81.40%(197),and 83.61%(301)during the period.Of all the positive samples,human enterovirus 71(EV71)accounted for 29.25%(31),25%(26),32.99%(65),and 1.33%(4);coxasckievirus A 16(CoxA16)accounted for 42.45%(45),30.77%(32),46.70%(92),and 66.11%(199);and other enterovirus accounted for 28.30%(30),44.23%(46),20.30%(40),and 32.56%(98),respectively.Conclusion CoxA16 was the dominant pathogen of HFMD in Liaoyang from 2010 through 2013,but the proportion of other enterovirus was high and.enotyping for the pathogens of HFMD should be strengthened in the area.