Abstract:
Objective To study the clinical significance of carcino-embryonic antigen related cellular adhesion molecule 19(CEACAM19)mRNA and the relationship between the CEACAM19 mRNA expression,estrogen receptor(ER),progestrone receptor(PR),human epidermal growth factor receptor type 2(Her-2),and carbohydrate atigen 15-3(CA15-3) among breast cancer patients.
Methods Totally 130 newly pathologically diagnosed breast cancer patients aged 32-70 years were recruited at a hospital from October 2008 to October 2014;52 metastatic lymph node and 130 primary breast cancer tissue specimens were collected from the patients for the detection of CEACAM19 mRNA expression with real-time PCR and the expressions of ER,PR,Her-2,CA15-3 were also measured simultaneously for most of the patients.
Results The average expression of CEACAM19 mRNA in 52 metastatic lymph nodes was significantly higher than that in primary breast cancer tissues(0.788±0.87 vs.0.431±0.381,
t=-3.289;
P<0.05).Of the 115 patients with ER detection,80 were ER-positive;the ER-positive patients had a significantly lower proportion of high CEACAM19 mRNA expression(42.5%,34/80) compared to that of the ER-negative patients(68.6%,24/35)(
P<0.05).No significant correlations were observed between the expression of CEACAM19 mRNA and detection results of PR,Her-2,and CA15-3.
Conclusion CEACAM19 mRNA expression correlates with ER expression among breast cancer patients.