广西巴马人群血脂与Apo CⅠ基因rs4420638位点多态性关系
Relationship between apolipoprotein C-I gene rs4420638 polymorphism and blood lipids among healthy adults in Bama county of Guangxi
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摘要: 目的 探讨载脂蛋白CⅠ(Apo CⅠ)基因的rs4420638位点多态性与广西巴马人群血脂的关系。方法 2008年4-8月从广西巴马县选取健康个体369人作为研究对象,用TaqMan MGB实时荧光PCR技术对研究对象进行基因位点分型,比较巴马人群等位基因频率及血脂水平与对照组的差异。结果 巴马组G等位基因频率为8.3%,低于对照组的13.9%(P=0.002),巴马组高密度脂蛋白胆固醇(HDL-C)水平为1.46 mmol/L,明显高于对照组的1.11 mmol/L(P<0.01);巴马组rs4420638位点G等位基因携带人群血清总胆固醇(TC)水平为4.59 mmol/L,低于对照组的5.23 mmol/L(P<0.05),A等位基因携带人群HDL-C水平为1.46 mmol/L,高于对照组的1.13 mmol/L(P<0.01)。结论 Apo CⅠ基因rs4420638位点多态性可能是影响巴马人群血脂水平的因素。Abstract: Objective To investigate the correlation between apolipoprotein C-Ⅰ(ApoCⅠ) gene rs4420638 polymorphism and blood lipids level among healthy adults in Bama county.Methods A total of 369 healthy adults were randomly selected from Bama county of Guangxi Zhuang Autonomous Region and 216 healthy adults without familial history of longevity were selected as controls from a county near Bama and with similar environmental conditions.The genotypes of ApoCⅠ(rs4420638) were detected with TaqMan real-time quantitative PCR.The differences in allele frequencies and blood lipid level between the adults of Bama county and the controls were analyzed.Results The frequency of allele G of ApoCⅠgene rs4420638 among the adults in Bama county was lower than that of the controls(P=0.002).The level of high-density lipoprotein cholesterol(HDL-C) was significantly higher in the adults of Bama county than that in the controls(P<0.01).The level of total cholesterol(TC) of Bama adults being rs4420638 G allele carriers was lower than that of the controls(P<0.05) and the level of HDL-C of Bama adults being rs4420638 A allele carriers was higher than that of the controls(P<0.01).Conclusion ApoCⅠrs4420638 polymorphism may associate with blood lipids level in healthy adults of Bama county.
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