Abstract: Objective To examine common pathogens of febrile respiratory syndrome in Panjin municipality of Liaoning province and to provide bases for clinical diagnosis, treatment and prevention of the disease.Methods Clinical specimens were collected from outpatients with febrile respiratory syndrome in Panjin Municipal Central Hospital between 2013 and 2014.PCR technology was used in pathogen detection.Results Of the 150 specimens, 76 were positive for nucleic acids of 12 pathogens, with a detection rate of 50.7%, and of the pathogen positive specimens, 14.5% were multiple pathogen positive.For the 76 positive specimens, the pathogens included influenza virus(16, 10.7%), Streptococcus pneumoniae(13, 8.7%), Staphylococcus aureus(6.0%), adenovirus(8, 5.3%), rhinovirus(7, 4.7%), Mycoplasma pneumonia(6, 4.0%), parainfluenza virus(6, 4.0%), synthetic syncytial virus(3, 2.0%), coronavirus(3, 2.0%), Haemophilus influenzae(2, 1.3%), partial lung virus(2, 1.2%), and Mycoplasma pneumoniae(1, 0.7%).Conclusion There are multiple pathogens for respiratory tract infections in Panjin municipality and the main pathogens are influenza virus, Streptococcus pneumoniae, Staphylococcus aureus, and adenovirus.