Abstract: Objective To investigate the prevalence and influencing factors of chronic fatigue syndrome(CFS) among civil servants in Yinzhou district of Ningbo city.Methods A self-administered questionnaire survey was conducted among 1 022 active civil servants working in government departments of Yinzhou district to screen CFS and the suspected CFS cases were then examined by psychosomatic medical doctors for definite diagnosis.Results The prevalence rate of CFS in the civil servants was 6.07% and the rate of the female civil servants was higher than that of the male(7.57% vs. 4.62%, χ²=3.91;P<0.05);the rate of CFS decreased with the increment of age(χ²=40.676, P=0.000).The risk factors of CFS among the civil servants were aged ≤30 years, having working stress, and with low satisfaction to personal social status, with the odds ratios of 29.372, 2.719, and 3.995, respectively.Conclusion The prevalence rate of CFS among the civil servants in Ningbo city is at a moderate level and influenced by age and mental health status.Special attention should be paid to CFS among young civil servants.