Abstract: Objective To examine the prevalence and distribution of cancer-related risk factors among residents in Jiangbei district of Ningbo city and to provide evidences for effective prevention and control of cancers.Methods Cluster randomized sampling method was adopted to investigate 10 583 residents aged 40-69 years in two communities of Jiangbei district with questionnaire survey and physical examination.Results Among the participants,the prevalences of smoking,alcohol drinking,lack of physical exercise,overweight,and obesity were 24.76%,28.26%,50.20%,35.42%,and 7.37%,respectively,with significant age- and gender-differences in the prevalences (all P<0.001).Among 34.39% of the participants with the detection of hepatitis B surface antigen the positive rate was 17.64%,with significant age- and gender-differences in the positive rate (both P<0.001).The prevalences of chronic bronchitis,emphysema,other chronic respiratory diseases,superficial gastritis,duodenal ulcer,gastric stump,cirrhosis,and fatty liver was 7.20%,1.03%,4.40%,14.16%,1.97%,0.20%,0.49%,and 13.23%,respectively,with significant gender-differences in the prevalences (all P<0.001).The prevalences of bronchial asthma,silicosis or pneumoconiosis,other upper digestive system diseases,and chronic hepatitis C was 1.92%,0.80%,2.56%,and 0.23%,respectively,with significant age-differences in the prevalences (all P<0.05).The prevalences of gastric ulcer,chronic hepatitis B,and gall stone disease was 5.65%,4.25%,and 7.80%,with significant age- and gender-differences in the prevalences (all P<0.05).Conclusion The prevalences cancer-related risk factors are high but the knowledge about cancer screening is low among the residents in Jiangbei district of Ningbo city,suggesting specific intervention measures should be taken to reduce the incidence of cancer among the residents.