XPG基因多态性与贲门癌遗传易感性关系

周荣秒; 王娜; 黄茜; 刘亮; 李宏; 霍向然; 李琰

doi:10.11847/zgggws2016-32-10-27

XPG基因多态性与贲门癌遗传易感性关系

Association between XPG gene polymorphisms and susceptibility to gastric cardiac adenocarcinoma

摘要

摘要: 目的探讨着色性干皮病基因组G（XPG）rs751402 C/T与rs873601 G/A单核苷酸多态性（SNP）与河北省磁县高发区人群贲门腺癌（GCA）遗传易感性之间的关系。方法采用聚合酶链反应-连接酶检测反应（PCR-LDR）方法对431例GCA患者和432名健康对照XPG基因rs751402 C/T和rs873601 G/A SNP进行基因分型。结果 XPG基因rs751402 C/T SNP T/T基因型增加了≤61岁年龄组个体GCA的发病风险（OR=1.77，95%CI=1.12～3.30）。XPG基因rs873601 G/A SNP与GCA的发病风险无关。结论携带XPG基因rs751402 C/T SNP T/T基因型个体GCA的发病风险明显增加，应定期接受上消化道内镜检查，以便实现GCA的早诊早治。

Abstract: Objective To evaluate the association of xeroderma pigmentosum group G (XPG) gene rs751402 C/T and rs873601 G/A single nucleotide polymorphism (SNP) with the risk of gastric cardiac adenocarcinoma (GCA) in a population of Ci county with high incidence of GCA in Hebei province.Methods XPG gene rs751402 and rs873601 were genotyped with polymerase chain reaction ligase detection reaction (PCR-LDR) method in 431 GCA patients and 432 gender- and age-matched healthy controls.Results The younger individuals (≤61 years old) with XPG rs751402 T/T genotype showed an increased risk of GCA (adjusted odds ratio OR=1.77,95% confidence interval 95% CI=1.12-3.30).No association of XPG rs873601 SNP with the susceptibility to GCA was observed either in overall analysis or in stratification analysis among the participants.Conclusion The XPG rs751402 T/T genotype carriers may have a higher risk of GCA.

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