高级检索
顾晓平, 王银存, 智恒奎, 覃玉, 周金意, 武鸣. 大丰市食管癌、胃癌发病危险因素及其聚集性病例对照研究[J]. 中国公共卫生, 2016, 32(10): 1406-1409. DOI: 10.11847/zgggws2016-32-10-28
引用本文: 顾晓平, 王银存, 智恒奎, 覃玉, 周金意, 武鸣. 大丰市食管癌、胃癌发病危险因素及其聚集性病例对照研究[J]. 中国公共卫生, 2016, 32(10): 1406-1409. DOI: 10.11847/zgggws2016-32-10-28
shu
GU Xiao-ping, WANG Yin-cun, ZHI Heng-kui.et al, . Risk factors of esophageal and stomach cancer and their clustering in Dafeng municipality: a case-control study[J]. Chinese Journal of Public Health, 2016, 32(10): 1406-1409. DOI: 10.11847/zgggws2016-32-10-28
Citation: GU Xiao-ping, WANG Yin-cun, ZHI Heng-kui.et al, . Risk factors of esophageal and stomach cancer and their clustering in Dafeng municipality: a case-control study[J]. Chinese Journal of Public Health, 2016, 32(10): 1406-1409. DOI: 10.11847/zgggws2016-32-10-28
shu

大丰市食管癌、胃癌发病危险因素及其聚集性病例对照研究

Risk factors of esophageal and stomach cancer and their clustering in Dafeng municipality: a case-control study

    摘要
  • 摘要: 目的 了解江苏省大丰市食管癌和胃癌发病的危险因素及其危险因素聚集性与癌症发生的关系，为当地食管癌和胃癌的预防控制提供参考依据。方法 采用以人群为基础病例对照研究方法对2002年10月-2010年11月大丰市疾病预防控制中心肿瘤登记系统登记的所有526例新发食管癌和504例新发胃癌患者及同期在当地公安户籍人口数据库中随机抽取的607和629名无消化系统疾病的健康居民进行问卷调查。结果 在调整了性别、年龄、文化程度、婚姻状况和10年前年人均收入等混杂因素后，多因素条件logistic回归分析结果显示，不按时进食、进食速度快、吃烫食、吸烟和饮酒是大丰市食管癌发病的危险因素，进食速度快、吃烫食、吃咸食、从不生吃大蒜和吸烟是大丰市胃癌发病的危险因素；病例组食管癌和胃癌患者有3、≥4个危险因素的比例分别为32.5%和41.1%、17.9%和19.0%，均高于对照组人群比例的26.2%和35.3%、7.1%和7.0%，差异均有统计学意义（均P<0.001）；在调整了混杂因素后，多因素logistic回归分析结果显示，有3和≥4个危险因素聚集者发生食管癌的风险分别为有≤1个危险因素者的2.58倍（OR=2.58，95%CI=1.80～3.69）和5.34倍（OR=5.34，95%CI=3.34～8.55），有3和≥4个危险因素聚集者发生胃癌的风险分别为有≤1个危险因素者的2.14倍（OR=2.14，95%CI=1.44～3.18）和5.05倍（OR=5.05，95%CI=3.05～8.36）。结论 进食速度快、吃烫食和吸烟是大丰市食管癌和胃癌发病的共同危险因素；随着危险因素聚集增多，食管癌和胃癌的发病风险明显上升。

     

    Abstract: Objective To analyze risk factors of esophageal and gastric cancer and the clustering of these factors in Dafeng municipality of Jiangsu province and to provide references for prevention and control of esophageal and gastric cancer.Methods A case-control study was conducted among 526 and 504 first-diagnosed esophageal and stomach cancer patients registered in population-based cancer registry and 607 and 629 age-,gender-matched healthy controls randomly selected from permanent local residents during October 2002 to November 2010;all participants were interviewed face-to-face with a self-designed questionnaire.Results Unconditional logistic regression analysis showed that irregular eating,eating fast,preference for hot and salty food,cigarette smoking,and alcohol drinking were risk factors for esophageal cancer and eating fast,preference for hot and salty food,not eating garlic,and cigarette smoking were risk factors for stomach cancer after adjusting for gender,age,education level,marriage and annual household income ten-year ago.There were significant differences between the cases and the controls in the proportions of having 3 risk factors (32.5% vs.26.2%) and ≥4 risk factors (17.9% vs.7.0%) for esophageal cancer and having 3 risk factors (41.1% vs.35.3%) and ≥4 risk factors (19.0% vs.7.1%) for gastric cancer,respectively (P<0.001 for all);the results of unconditional logistic regression analysis also showed that after adjusting confounding factors,the participants with 3 and ≥4 risk factors of esophageal or gastric cancer had significantly increased risk of esophageal cancer (odds ratioOR=2.58,95% confidence interval95%CI=1.80-3.69 and OR=5.34,95%CI=3.34-8.55) or gastric caner (OR=2.14,95%CI=1.44-3.18 and OR=5.05,95%CI=3.05-8.36) compared to those with ≤1 relevant risk factors.Conclusion Eating fast,preference for hot eating and cigarette smoking are common risk factors for esophageal and stomach cancer and the cancer risk increases with the increment of the number of risk factors in the population of Dafeng municipality.

     

    • HTML全文
    • 参考文献(13)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回