Abstract: The epidemic of overweight and obesity in women of childbearing age is outstanding and has become a global health concern.Moreover,studies have shown that pre-pregnancy obesity and excessive weight gain during pregnancy increase the risk of neurodevelopmental disorders of offspring.However,the mechanism underlying maternal overweight or obesity-induced neurodevelopmental disorders is not clear.Emerging researches suggest that systemic and placental inflammation caused by maternal overweight or obesity may mediate the occurrence of offspring neurodevelopmental disorders.This review focuses on maternal systemic and placental inflammation caused by pre-pregnancy and excessive weight gain during pregnancy,and how these inflammations result in neurodevelopmental disorders in the offspring.