高级检索
祁志宇, 张丽倩, 何英杰, 于乐, 党翠玲. 承德地区HPV感染及危险因素分析[J]. 中国公共卫生, 2016, 32(12): 1669-1673. DOI: 10.11847/zgggws2016-32-12-17
引用本文: 祁志宇, 张丽倩, 何英杰, 于乐, 党翠玲. 承德地区HPV感染及危险因素分析[J]. 中国公共卫生, 2016, 32(12): 1669-1673. DOI: 10.11847/zgggws2016-32-12-17
QI Zhi-yu, ZHANG Li-qian, HE Ying-jie.et al, . Prevalence and risk factors of human papilloma virus infection among women in Chengde city[J]. Chinese Journal of Public Health, 2016, 32(12): 1669-1673. DOI: 10.11847/zgggws2016-32-12-17
Citation: QI Zhi-yu, ZHANG Li-qian, HE Ying-jie.et al, . Prevalence and risk factors of human papilloma virus infection among women in Chengde city[J]. Chinese Journal of Public Health, 2016, 32(12): 1669-1673. DOI: 10.11847/zgggws2016-32-12-17

承德地区HPV感染及危险因素分析

Prevalence and risk factors of human papilloma virus infection among women in Chengde city

  • 摘要: 目的 了解河北省承德市女性宫颈人乳头瘤病毒(HPV)感染情况,分析HPV感染的危险因素,为HPV感染及宫颈癌防治提供理论依据。方法 于2013年1月-2016年1月在承德市8县3区选取4 250名女性进行问卷调查、液基薄层细胞学检查(TCT)及宫颈HPV DNA检测,对HPV16/18型和细胞学提示不能明确意义的非典型鳞状上皮细胞(ASCUS)、非典型腺上皮细胞(AGC)及以上患者进行阴道镜检查、组织活检及病理检查,分析不同宫颈病变及年龄组HPV感染情况,采用多因素logistic回归模型分析HPV感染危险因素。结果 承德地区4 250名妇女HPV感染819例,感染率为19.27%,最常见的5种HPV高危型别依次为16、58、52、39、51型。伴随宫颈上皮内瘤变(CIN)级别升高,HPV感染率升高,宫颈癌HPV感染率为100%。<20岁组HPV感染率最高,为21.74%;30~49岁及≥60岁组为HPV感染高峰。吸烟、首次性生活年龄过早、受教育程度低(高中以下)、接触性出血和宫颈柱状上皮异位为HPV感染的危险因素,避孕套避孕和了解宫颈癌及HPV为HPV感染的保护因素。结论 HPV感染与CIN及宫颈癌密切相关,加强对具有HPV感染危险因素人群的筛查及管理可有效预防宫颈癌的发生。

     

    Abstract: Objective To investigate the prevalence and risk factors of cervical human papilloma virus (HPV) among adult community women in Chengde municipality of Hebei province and to provide evidences for the prevention of HPV infection and cervical cancer.Methods During January 2013 and January 2016,4 250 female local residents aged 18-69 years were recruited from 8 counties and 3 districts in Chengde municipality and surveyed with a questionnaire interview,thin prep cytologic test (TCT) and HPV DNA genotyping;then vaginoscopy,biopsy and pathological examination were performed among the participants identified with HPV 16/18 infection,atypical squamous cells-undetermined significance (ASCUS),atypical glandular cells (AGC),and more severe manifestations.Logistic regression analy-sis was adopted to analyze risk factors of HPV infection.Results Of the women,819 had HPV infection and the infection rate was 19.27%,with the top five infection rates for high-risk HPV types of 16,58,52,39,and 51. HPV infection rate was increased with the severity of cervical intraepithelial neoplasia (CIN) and the HPV infection rate was 100% in the participants with cervical cancer. The participants less than 20 years old showed the highest HPV infection rate of 21.74% and those aged 30 to 49 years and above 60 years had higher infection rate than the women of other age groups. Smoking,having first sex at younger age,with the education of high school or below,and with uterine cervical contact bleeding and uterine cervical columnar ectopy were risk factors of HPV infection; while condom use for contraception and having the knowledge about cervical cancer and HPV infection were protective factors of HPV infection.Conclusion HPV infection is closely related to CIN and cervical cancer among the women in Chengde city and screening and control of HPV infection could effectively prevent the occurrence of cervical cancer in the population.

     

/

返回文章
返回