面对精准医学的大潮,流行病学研究方法准备好了吗?

Is the research method of epidemiology fully prepared for the era of precision medicine?

摘要: “精准医学”与流行病学关系密切。“精准医学”中的“精准预防”属流行病学的研究范畴。不仅如此，流行病学基于归纳推理的群体研究方法还是“精准医学”研究的共性技术。面对蓬勃兴起的“精准医学”大潮，流行病学这套适用于大人群疾病防制的研究方法尚不能完全适应针对个体的“精准医学”研究。本文以“精准预测”为例，介绍了流行病学研究方法在“精准医学”研究中存在的缺陷及现有的解决思路，以使我们能够在现有的方法学水平上完成“相对精准”的医学研究。

Abstract: Precision medicine has a strong relationship with epidemiology."Precision prevention",one part of "precision medicine",falls under the category of epidemiology.Moreover,the population-based method of epidemiology relying on inductive reasoning is the common technology of "precision medicine".In the era of "precision medicine",the research method of epidemiology,which is applicable to the prevention and control of diseases in large populations,cannot be fully adapted to the study of "precision medicine" focusing on individuals.This article,taking the "precision prediction" as an example,introduces the shortcomings of epidemiological methods existing in the "precision medicine" and provides possible solutions;therefore the "relative precision" medical research can be conducted based on the existing methodology.