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乔正学, 马靖松, 陈明琪, 杨佳润, 邱晓惠, 杨秀贤, 王琳, 杨艳杰. VEGFR2+1416 T/A基因多态性与抑郁症关系[J]. 中国公共卫生, 2017, 33(1): 122-124. DOI: 10.11847/zgggws2017-33-01-31
引用本文: 乔正学, 马靖松, 陈明琪, 杨佳润, 邱晓惠, 杨秀贤, 王琳, 杨艳杰. VEGFR2+1416 T/A基因多态性与抑郁症关系[J]. 中国公共卫生, 2017, 33(1): 122-124. DOI: 10.11847/zgggws2017-33-01-31
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QIAO Zheng-xue, MA Jing-song, CHEN Ming-qi.et al, . Association between gene polymorphism of vascular endothelial growth factor receptor 2 and susceptibility of major depressive disorders[J]. Chinese Journal of Public Health, 2017, 33(1): 122-124. DOI: 10.11847/zgggws2017-33-01-31
Citation: QIAO Zheng-xue, MA Jing-song, CHEN Ming-qi.et al, . Association between gene polymorphism of vascular endothelial growth factor receptor 2 and susceptibility of major depressive disorders[J]. Chinese Journal of Public Health, 2017, 33(1): 122-124. DOI: 10.11847/zgggws2017-33-01-31
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VEGFR2+1416 T/A基因多态性与抑郁症关系

Association between gene polymorphism of vascular endothelial growth factor receptor 2 and susceptibility of major depressive disorders

    摘要
  • 摘要: 目的 探讨血管内皮细胞生长因子受体2（VEGFR2）+1416 T/A基因多态性与抑郁症易感性的关系。方法 提取中国北方地区274名汉族单相抑郁症患者（病例组）和273例汉族健康对照者（对照组）基因组DNA，采用单碱基延伸SNP分型技术（SNaPshot）检测病例组和对照组VEGF R2+1416 T/A位点基因型，应用χ2检验比较病例组和对照组的基因型和等位基因频率分布的差异。结果 病例组和对照组VEGFR2+1416 T/A基因型A/A、A/T、T/T频率分布为26.3%、44.9%、28.8%和16.8%、54.6%、28.6%，差异有统计学意义（χ2=8.219，P=0.016），病例组和对照组VEGFR2+1416 T/A等位基因A、T频率分布为48.7%、51.3%和44.1%、55.9%，差异无统计学意义（χ2=2.310，P=0.129）。结论 VEGFR2+1416 T/A基因多态性与抑郁症有明显关联。

     

    Abstract: Objective To investigate the relationship between vascular endothelial growth factor receptor 2(VEGFR2)gene polymorphism and the susceptibility of major depression disorders.Methods We collected peripheral blood samples from 274 Han patients diagnosed with unipolar depression and 273 age- and gender-matched Han healthy controls in Northeast of China.Single base primer extension assay (Snapshot)was used to detect genotype frequency and allele frequency of VEGFR2+1416 T/A.χ2 test was used to analyze the difference in the distribution of genotype and allele between the cases and the controls.Results There was a significant difference between the cases and the controls in the frequency distribution of VEGFR2+1416 T/A genotype A/A(26.3% vs.16.8%),A/T(44.9% vs.54.6%),and T/T (28.8% vs.28.6%)(χ2=8.219,P=0.016).The frequency of VEGFR2+1416 T/A allele of A and T were 48.7% and 51.3% in the cases and 44.1% and 55.9% in the controls,without significant difference between the two groups (χ2=2.310,P=0.129).Conclusion The gene polymorphism of VEGFR2+1416 T/A is correlated significantly with the incidence of unipolar depression.

     

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