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王娟, 庄严, 巩会平, 刘振东, 杜贻萌. 山东济南地区35～75岁人群肥胖类型与动脉僵硬度关系[J]. 中国公共卫生, 2017, 33(3): 444-447. DOI: 10.11847/zgggws2017-33-03-27
引用本文: 王娟, 庄严, 巩会平, 刘振东, 杜贻萌. 山东济南地区35～75岁人群肥胖类型与动脉僵硬度关系[J]. 中国公共卫生, 2017, 33(3): 444-447. DOI: 10.11847/zgggws2017-33-03-27
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WANG Juan, ZHUANG Yan, GONG Hui-ping.et al, . Association of obesity with arterial stiffness in community populations aged 35-70 years in Ji'nan area,Shandong province[J]. Chinese Journal of Public Health, 2017, 33(3): 444-447. DOI: 10.11847/zgggws2017-33-03-27
Citation: WANG Juan, ZHUANG Yan, GONG Hui-ping.et al, . Association of obesity with arterial stiffness in community populations aged 35-70 years in Ji'nan area,Shandong province[J]. Chinese Journal of Public Health, 2017, 33(3): 444-447. DOI: 10.11847/zgggws2017-33-03-27
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山东济南地区35～75岁人群肥胖类型与动脉僵硬度关系

Association of obesity with arterial stiffness in community populations aged 35-70 years in Ji'nan area,Shandong province

    摘要
  • 摘要: 目的探讨山东省济南地区35～75岁人群肥胖类型与血脂促动脉硬化指数的相关性。方法2011年6月—2013年7月，采用整群随机抽样方法抽取山东省济南地区35～75岁人群 10 079人，测量受试者腰围、身高、体重、颈-股动脉的脉搏波速度（cfPWV）及空腹血脂指标，并计算体质指数（BMI）及血脂促动脉硬化指数（PAI）。结果BMI<28 kg/m2+非腹型肥胖组cfPWV及PAI分别为（9.15±1.62）m/s和（2.27±0.96），BMI<28 kg/m2+腹型肥胖组分别为（9.82±1.78）m/s和（2.56±1.18），BMI≥28 kg/m2+非腹型肥胖组分别为（9.45±1.82）m/s和（2.44±1.19），BMI≥28 kg/m2+腹型肥胖组分别为（10.99±1.91）m/s和（3.21±1.71）。与BMI<28 kg/m2+非腹型肥胖组比较，其余各组cfPWV及PAI明显升高（P<0.05）。与BMI<28 kg/m2+腹型肥胖组比较，BMI≥28 kg/m2+非腹型肥胖组cfPWV明显升高（P<0.05）。与BMI≥28 kg/m2+非腹型肥胖组比较，BMI≥28 kg/m2+腹型肥胖组cfPWV及PAI明显升高（P<0.05）。BMI及腰围对cfPWV及PAI共同效应有统计学意义（F=61.366、42.682，P<0.001）。以BMI<28kg/m2非腹型肥胖组为参照，在校正年龄、性别、收缩压、舒张压、FPG等因素后，BMI≥28 kg/m2非腹型肥胖组PAI>4及cfPWV>10m/s的OR值分别为1.649（95%CI=1.154～2.144）和1.551（95%CI=1.117～1.985），P均<0.001；BMI<28kg/m2腹型肥胖组OR值分别为1.764（95%CI=1.370～2.158）和1.577（95%CI=1.264～1.890），P均<0.001；BMI≥28 kg/m2腹型肥胖组OR值分别为5.666（95%CI=3.726～7.606）和4.631（95%CI=2.615～6.647），P均<0.001。结论在山东济南地区35～75岁人群中，单纯性肥胖及腹型肥胖均是动脉硬化的独立危险因素，腰围及BMI增加在致动脉硬化中具有协同作用。

     

    Abstract: ObjectiveTo investigate obesity type and the association of obesity with arterial stiffness in community populations aged 35-70 years in Ji'nan area,Shandong province.MethodsFrom June 2011 to July 2013,10 079 permanent residents aged 35-70 years were recruited from 24 communities in Ji'nan area of Shandong province using random cluster sampling.Waist circumference (WC),height,weight,carotid-femoral pulse wave velocity (cfPWV),and fasting blood lipids were measured in all the participants and body mass index (BMI) and plasma induced arterial stiffness index (PAI) were calculated.ResultsThe values of cfPWV and PAI were 9.15±1.62 m/s and 2.27±0.96 for the participants with BMI<28 kg/m2 and non-abdominal obesity (AO),9.82±1.78 m/s and 2.56±1.18 for those with BMI<28 kg/m2 and AO,9.45±1.82 m/s and 2.44±1.19 for BMI≥28 kg/m2 and non-AO,and 10.99±1.91 m/s and 3.21±1.71 for BMI≥28 kg/m2 and AO,respectively.Compared to those with BMI<28 kg/m2 and non-AO,the cfPWV and PAI were significantly increased in the participants with BMI<28 kg/m2 and AO,BMI≥28 kg/m2 and non-AO,and BMI≥28 kg/m2 and AO (P<0.05 for all).Compared to those with BMI<28 kg/m2 and AO,the cfPWV was significantly increased in the participants with BMI≥28 kg/m2 and non-AO (P<0.05).Compared to those with BMI≥28 kg/m2 and non-AO,the cfPWV and PAI were significantly increased in the participants with BMI≥28 kg/m2 and AO (both P<0.05).Significant joint effect of WC and BMI on cfPWV and PAI were observed (F=61.366 and 42.682,both P<0.001).Compared to those with BMI<28 kg/m2 and non-AO,the participants with BMI≥28 kg/m2 and non-AO presented significantly increased risks of PAI>4 (odd ratiosOR=1.649,95% confidence interval95% CI:1.154-2.144) and cfPWV>10m/s (OR=1.551,95% CI:1.117-1.985)(both P<0.001);the participants with BMI<28 kg/m2 and AO had significantly increased risks of PAI>4 (OR=1.764,95% CI:1.370-2.158) and cfPWV>10m/s (OR=1.577,95% CI:1.264-1.890)(both P<0.001);and the participants with BMI≥28 kg/m2 and AO had significantly increased risks of PAI>4 (OR=5.666,95% CI:3.726-7.606) and cfPWV>10m/s (OR=4.631,95% CI:2.615-6.647)(both P<0.001),after adjusting for age,gender,systolic blood pressure,diastolic blood pressure,and fasting plasma glucose.ConclusionBoth simple obesity and abdominal obesity are independent risk factors for arterial stiffness and there is a synergistic effect of WC and BMI on arterial stiffness in populations aged 35-70 years in Ji'nan area of Shandong province.

     

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