Abstract: Objective To investigate the risk factors of acute myocardial infarction (AMI) in elderly patients with coronary heart disease (CHD),and to provide references for relevant prevention and control measures.Methods From the patients visiting the Cardiovasology Department of The Third Affiliated Hospital of Qiqihaer Medical College,we randomly recruited 73 elderly CHD patients (aged ≥ 60 years) complicated with AMI as the case group and 132 CHD patients of the same ages as the control group between October 2013 and October 2016.Questionnaire survey,physical examination and related laboratory measurements were conducted among the participants.Multivariate logistic regression model was used to analyze the risk factors of AMI.Results The high sensitive C reactive protein (hs-CRP) and serum creatinine (SCr) of the case group were 7.02±1.83 mmol/L and 94.23±19.23 mmol/L,and were significantly higher than those of the control group (4.56±0.89 mmol/L and 88.27±16.06 mmol/L)(both P<0.05).Multivariate logistic regression analysis showed that smoking,hypertension,diabetes,family history of cardiovascular disease and high hs-CRP were independent risk factors of AMI.Conclusion Smoking,hypertension,diabetes,family history of cardiovascular disease and high hs-CRP could increase the risk of AMI among elderly CHD patients.