Abstract: The aim of the study is to provide a solution for the production of infectious disease emergency-related appliances.The study constructs a spatial diffusion model of infectious disease pandemic according to knowledge spillover theory and then,we builds a forecasting model of infectious disease pandemic based on the exploration of the diffusion process of infectious disease pandemics in China.Finally,we use Microsoft Visual Basic for Applications(VBA)programming technology to estimate the degree of spatial diffusion of infectious disease pandemic and to predict the incidents of infectious disease pandemic.