Dyslipidemia prevalence and serum lipid profiles and ratios among urban and rural residents in Hubei province,2013:a comparison analysis
-
摘要: 目的 了解湖北省2013年城乡居民血脂异常患病率及血脂水平和比值分布特征差异,为血脂异常的防制工作提供科学依据。方法 于2013年7—10月采用多阶段整群随机抽样方法,在湖北省疾病监测点系统覆盖的10个县(市、区)抽取5 926名≥18周岁城乡居民进行问卷调查和实验室检测。利用SAS 9.2基于设计的复杂抽样模块进行统计分析。结果 经复杂加权计算后,湖北省2013年城乡居民血脂异常患病率为32.7%,其中高总胆固醇(TC)血症、高甘油三酯(TG)血症、高低密度脂蛋白胆固醇(LDL-C)血症和低高密度脂蛋白胆固醇(HDL-C)血症患病率分别为4.5%、12.3%、5.8%和21.6%。2013年湖北省城乡居民血清中TC、TG、LDL-C、HDL-C和非高密度脂蛋白胆固醇(non-HDL-C)的水平分别为(4.55±0.09)、(1.44±0.05)、(2.76±0.07)、(1.35±0.04)和(3.20±0.07)mmol/L。不同地区居民比较,城市居民TG水平[(1.57±0.06)mmol/L]高于农村居民[(1.26±0.03)mmol/L],HDL-C水平[(1.28±0.02)mmol/L]低于农村居民[(1.46±0.06)mmol/L],差异均有统计学意义(均P<0.01);城市不同性别居民比较,男性居民TG和non-HDL-C水平[(1.82±0.09)和(3.34±0.07)mmol/L]均高于女性居民[(1.30±0.04)和(3.11±0.06)mmol/L],HDL-C水平[(1.21±0.02)mmol/L]低于女性居民[(1.35±0.03)mmol/L],差异均有统计学意义(均P<0.01);农村不同性别居民比较,男性居民HDL-C水平[(1.41±0.05)mmol/L]低于女性居民[(1.51±0.07)mmol/L],差异有统计学意义(P<0.01)。血脂比值TC/HDL-C、LDL-C/HDL-C、non-HDL-C/HDL-C和TG/HDL-C分别为3.67、2.20、2.67和1.45;其中,男性居民分别为3.93、2.33、2.93和1.81,均高于女性居民的3.41、2.07、2.41和1.08,城市居民分别为3.85、2.29、2.85和1.69,均高于农村居民的3.39、2.07、2.39和1.07,差异均有统计学意义(均P<0.01)。结论 湖北省城乡居民血脂异常率较高;城市居民TG水平高于农村居民,HDL-C水平低于农村居民;各项血脂比值男性均高于女性,城市居民均高于农村居民。Abstract: Objective To compare the dyslipidemia prevalence,serum lipid profiles and ratios between urban and rural residents in Hubei province in 2013 and to provide evidences for the prevention and control of dyslipidemia.Methods Questionnaire survey and laboratory test were conducted among 5 926 urban or rural residents aged 18 and over selected with multi-stage cluster random sampling from 10 disease surveillance points (DSPs) in Hubei province in 2013.SAS 9.2 was used for statistical analysis through design-based complex sampling module.Results After complex weighting,the overall dyslipidemia prevalence rate in urban and rural residents in Hubei province was 32.7%.The prevalence rates for high total cholesterol (TC),triglyceride (TG),low density lipoprotein-cholesterol (LDL-C) and low high density lipoprotein-cholesterol (HDL-C) were 4.5%,12.3%,5.8%,and 21.6%,respectively.The level of serum TC,TG,LDL-C,HDL-C and non-HDL-C were 4.55±0.09,1.44±0.05,2.76±0.07,1.35±0.04,and 3.20±0.07 mmol/L,respectively.The urban residents had significantly higher levels of serum TG (1.57±0.06 vs.1.26±0.03 mmol/L),lower levels of serum HDL-C (1.28±0.02 vs.1.46±0.06 mmol/L) than rural residents (both P<0.01).The male urban residents had higher levels of TG (1.82±0.09 vs.1.30±0.04 mmol/L),non-HDL-C (3.34±0.07 vs.3.11±0.06 mmol/L),lower levels of serum HDL-C (1.21±0.02 vs.1.35±0.03 mmol/L) than female urban residents (P<0.01 for all).The male rural residents had a lower level of serum HDL-C (1.41±0.05 vs.1.51±0.07 mmol/L) than female rural residents(P<0.01).The ratios of TC/HDL,LDL/HDL,non-HDL/HDL,TG/HDL were 3.67,2.20,2.67,and 1.45,respectively,which were all higher among the male residents (3.93,2.33,2.93,and 1.81) than among the female residents (3.41,2.07,2.41,and 1.08) and higher among urban residents (3.85,2.29,2.85,and 1.69) than among rural residents (3.39,2.07,2.39,and 1.07),with statistically differences.Conclusion The dyslipidemia prevalence was high among residents in Hubei province.Compared to rural residents,urban residents showed higher serum TG and lower serum HDL-C.All lipid ratios were higher in male residents than in female residents and higher in urban residents than in rural residents.
-
Key words:
- serum lipid level /
- ratio /
- distribution characteristics /
- urban and rural residents
-
[1] 王宇,梁晓峰.全国疾病监测系统死因监测数据集2012[M].北京:科学普及出版社,2013:28-39. [2] 王宇,孟群.中国死因监测数据集2013[M].北京:科学普及出版社,2015:26-37. [3] 王宇,孟群.中国死因监测数据集2014[M].北京:科学普及出版社,2015:26-37. [4] 李剑虹,米生权,李镒冲,等.2010年我国成年人血脂水平及分布特征[J].中华预防医学杂志,2012,46(7):607-612. [5] 赵文华,宁光.中国慢病监测(2010)项目国家项目工作组.2010年中国慢性病监测项目的内容与方法[J].中华预防医学杂志,2010,46(5):477-479. [6] 王抒,李红霞,满永,等.北京部分职业人群血清非高密度脂蛋白胆固醇参考值及其分布[J].中国动脉硬化杂志,2004,12(6):719-722. [7] 《中国成人血脂异常防治指南》制订联合委员会.中国成人血脂异常防治指南[M].北京:人民卫生出版社,2007:12-13. [8] 张庆军,张岚.湖北省慢性病及其危险因素监测报告2010[M].武汉:湖北科学技术出版社,2013:93-94. [9] 龚晨睿,程茅伟,宋毅,等.湖北省居民体质指数与血脂水平的状况研究[J].公共卫生与预防医学,2009,20(4):14-16. [10] 陶然,周金意,苏健,等.江苏省成年人血脂异常与糖尿病关系[J].中国公共卫生,2015,31(5):558-562. [11] 孙威风.甘肃省成人血脂异常流行病学调查[D].兰州:兰州大学硕士学位论文,2016. [12] 周海滨,莫俊銮,王俊,等.深圳市居民血脂异常流行病学调查[J].中国公共卫生,2011,27(11):1364-1366. [13] 杨雪莹,王亭,王亚平.天津市成年居民血脂异常流行特征及影响因素分析[J].中国公共卫生,2016,32(3):286-290. [14] 中国疾病预防控制中心慢性非传染性疾病预防控制中心.中国慢性病及其危险因素监测报告2013[M].北京:军事医学科学出版社,2016:71-73. [15] Brunzell JD,Davidson M,Furberg CD,et al.Lipoprotein management in patients with cardiometabolic risk:consensus statement from the American Diabetes Association and the American College of Cardiology Foundation[J].Diabetes Care,2008,31(4):811-822. [16] Sniderman AD,Williams K,Contois JH,et al.A meta-analysis of low-density lipoprotein cholesterol,non-high-density lipoprotein cholesterol,and apolipoprotein B as markers of cardiovascular risk[J].Circ Cardiovasc Qual Outcomes,2011,4(3):337-345. [17] 刘洋,郭阳.非高密度脂蛋白胆固醇与心脑血管疾病关系研究进展[J].中国卒中杂志,2015,10(9):799-803. [18] 张娜娜,冯燕娴.非高密度脂蛋白胆固醇在冠心病风险评估中的价值[J].东南大学学报:医学版,2015,34(3):462-465. [19] 任洁,赵冬,刘静,等.非高密度脂蛋白胆固醇水平与中国人群心血管病发病危险的相关性[J].中华心血管病杂志,2010,38(10):934-938. [20] Ito T,Arima H,Fujiyoshi A,et al.Relationship between non-high-density lipoprotein cholesterol and the long-term mortality of cardio-vascular diseases:NIPPON DATA 90[J].Int J Cardiol,2016,220:262-267. [21] Third Report of the National Cholesterol Education Program(NCEP) Expert Panel on Detection,Evaluation,and Treatment of High Blood Cholesterol in Adults(Adult Treatment Panel Ⅲ)final report[J].Circulation,2002,106(25):3143-3421. [22] Jacobson TA,Ito MK,Maki KC,et al.National Lipid Association recommendations for patient-centered management of dyslipidemia:part 1-executive summary[J].J Clin Lipidol,2014,8(5):473-488. [23] Millan J,Pinto X,Munoz A,et al.Lipoprotein ratios:physiological significance and clinical usefulness in cardiovascular prevention[J].Vasc Health Risk Manag,2009,5:757-765. [24] Wekesa C,Asiki G,Kasamba I,et al.Atherogenic risk assessment among persons living in rural Uganda[J].J Trop Med,2016,2016:7073894. [25] Ray KK,Cannon CP,Cairns R,et al.Prognostic utility of apoB/AI,total cholesterol/HDL,non-HDL cholesterol,or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes:results from PROVE IT-TIMI 22[J].Arterioscler Thromb Vasc Biol,2009,29(3):424-430. [26] 杨絮,张勇刚.低密度脂蛋白C、非高密度脂蛋白C、动脉硬化指数与冠心病严重程度的相关性分析[J].汕头大学医学院学报,2016,29(1):27-29. [27] Di Bonito P,Moio N,Scilla C,et al.Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children[J].Diabetes Care,2012,35(1):158-162.
点击查看大图
计量
- 文章访问数: 1233
- HTML全文浏览量: 185
- PDF下载量: 82
- 被引次数: 0