Abstract: Objective To examine the prevalence and influencing factors of breast diseases of among married childbearing women in rural Qiannan area of Guizhou province for implementing effective interventions.Methods A total of 99 887 married reproductive women (aged 17-45 years) were randomly selected in rural Qiannan area with stratified multi-stage cluster sampling and surveyed with questionnaire interview,physical examination,breast ultrasonography,near infrared scanner examination,mammography,and biopsy test for diagnosis of breast diseases from March 2015 to February 2017.SAS 9.1 was used in data analyses.Results Among all the participants,the crude and standardized prevalence rate of breast diseases were 33.45% (33 417/99 887) and 33.31%.Of the 33 417 participants diagnosed with breast diseases,86.09% (28 771) suffered from hyperplasia of mammary glands,6.93% (2 317) from mammary gland fibroma,5.91% (1 975) from papilloma,0.51% (169) form lobular atrophy,0.24% (79) from galactoma,0.04% (12) from mammitis,0.15% (51) from precancerous lesions,and 0.13% (43) with breast cancer,respectively.The results of multivariate unconditioned logistic regression analysis showed that the risk factors of breast diseases among the participants included at age of 30 to 39 years,being Miao nationality,having anxiety,with inpatient character,having corset,alcohol drinking,with a body mass index of ≥24.0 kg/m²,preference of fish and meat food,with a sleeping time of <7 hours per day,with a menstrual cycle of >28 days,having menorrhagia,with severe dysmenorrhea,having menarche before the age of 13 years,having a marriage before age of 25 years,with a primiparous age of > 25 years,having 2 pregnancies or less,having 2 abortions or less,having 2 full term pregnancies or less,having 2 deliveries or less,giving breastfeeding to 2 children or less,having a cumulative lactation duration of ≤36 months,suffering from gynecological disease,and living in the mountainous areas.Conclusion Special attention should be paid to the high prevalence rate of breast diseases among married childbearing women in rural Qiannan area of Guizhou province.