Distribution of pathogenic bacteria causing lower respiratory tract infections among neurology inpatients
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摘要: 目的 神经内科下呼吸道感染住院患者的病原菌分布特征,为促进患者的合理用药提供参考依据。方法 采用方便抽样自大连市选取2家三级甲等医院,随机选取2014年1月1日—2015年12月31日神经内科住院患者合并下呼吸道感染的病历1 600份,提取病原菌分布相关信息。结果 共分离出病原菌2 109株,其中革兰阴性菌1 372株,以肺炎克雷伯菌(17.16%,362/2 109)居多;革兰阳性菌624株,以金黄色葡萄球菌(14.32%,302/2 109)居多;真菌113株,以白色假丝酵母菌(2.66%,56/2 109)居多。71.85%(217/302)的金黄色葡萄球菌感染患者进行了耐药性分析,耐药率最低的为万古霉素(0.00%,0/217);78.73%(285/362)的肺炎克雷伯菌感染患者进行了耐药性分析,耐药率最低的为美罗培南(3.16%,9/285)。结论 加强住院患者病原菌的监测和耐药性分析,将有助于促进合理用药、预防医院感染,提高治疗的安全性和有效性。Abstract: Objective To study distributive characteristics of pathogenic bacteria causing lower respiratory tract infection in neurology inpatients and to provide evidences for promoting rational drug use.Methods Two third-grade class-A hospitals were selected with convenience sampling in Dalian city of Liaoning province; then 1 600 neurology inpatients with lower respiratory tract infections during hospitalization between January 1st,2014 through December 31st,2015 were selected randomly and their medical records were extracted and analyzed.Results Of the 2 109 strains of pathogenic bacteria totally isolated from the inpatients,1 372 and 624 were gram-negative and gram-positive bacteria and 113 were fungi,with 362 (17.16% of all the isolates) Klebsiella pneumoniae strains,302 Staphylococcus aureus (14.32%),and 113 Candida albicans (2.66%),respectively.Drug resistance was performed for 71.85% (217/302) and 78.73% (285/362) of the isolated Staphylococcus aureus and Klebsiella pneumoniae strains; no Staphylococcus aureus strains resistant to vancomycin were detected and only 3.16% of Klebsiella pneumoniae strains were resistant to meropenem.Conclusion Pathogen surveillance and drug resistance test for isolated pathogens among inpatients may promote rational drug use and nosocomial infection prevention.
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Key words:
- neurology /
- inpatient /
- pathogen /
- drug resistance
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[1] Yan L,Qing Y,Xingyi J,et al.Etiologic diagnosis and clinical treatment of multiple drug-resistant bacteria infection in elderly patients with stroke-associated pneumonia after neurosurgery[J].Cell Biochem Biophys,2015,71(2):731-734. [2] 张希玉.神经内科下呼吸道感染危险因素研究[J].中国病原生物学杂志,2013,8(7):641-643. [3] 王海涛,宫建,杨传家,等.三级甲等医院甲状腺疾病手术患者抗生素药物利用分析[J].中国公共卫生,2013,29(5):736-737. [4] 孙云萍,潘雯,宫建,等.沈阳市某二级甲等医院妇产科围手术期抗菌药物不良事件的调查分析[J].中华妇幼临床医学杂志(电子版),2013,9(5):624-627. [5] 张伟,潘雯,宫建,等.某基层二级甲等医院妇产科围手术期患者抗菌药物治疗方案的调查分析[J].中国医药导刊,2013,15(3):469-470. [7] 薛菊兰,王向荣,艾彪,等.神经内科患者下呼吸道感染病原体监测及耐药性分析[J].中华医院感染学杂志,2014,24(20):5016-5018. [8] 陈兰,王婷,朱英.医院感染细菌分布及耐药性分析[J].中国公共卫生,2013,29(11):1715-1716. [9] Pereira SG,Marques M,Pereira J,et al.Multidrug and extensive drug resistance in Pseudomonas aeruginosa clinical isolates from a Portuguese central hospital:10-year survey[J].Microb Drug Resist,2015,21(2):194-200. [10] Karimzadeh I,Mirzaee M,Sadeghimanesh N,et al.Antimicrobial resistance pattern of Gram-positive bacteria during three consecu-tive years at the nephrology ward of a tertiary referral hospital in Shiraz,Southwest Iran[J].J Res Pharm Pract,2016,5(4):238-247. [11] 杨文辰,宫建,孙晓辉,等.神经外科患者围手术期抗菌药物应用时间的调查分析[J].中华临床医师杂志(电子版),2016,(3):313-316. [12] 郑玉荣,宫建,陆锁兴,等.二级甲等医院妇产科围手术期患者的临床特征及抗菌药物使用分析[J].中华妇幼临床医学杂志,2012,8(5):515-517. [13] 宫建,潘雯,倪健辉,等.某三级甲等医院妇产科围术期患者应用抗菌药物的经济学评价[J].中国医院用药评价与分析,2012,12(8):678-680. [14] 邱新野,尹月,朱晓虹,等.85例注射用万古霉素使用合理性分析[J].北京医学,2016,38(12):1348-1349.
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