Abstract: Objective To explore related factors of high risk sexual behaviors among amphetamine-type stimulant (ATS) addicts and to provide evidences for future intervention.Methods Totally 1 677 ATS addicts in Shanghai Compulsory Isolated Detoxification Center were recruited and divided into a high risk group (697 with two or more sexual partners during recent one year and never using condom in sexual activity during recent one month)and a non-risk group (980);all the participants were surveyed with a questionnaire on demographic characteristics and drug use history and Barratt Impulsiveness Scale (BIS-Ⅱ) between August 2013 and December 2014.Logistic regression analysis was used to assess discrepant variables between the two groups.Results The participants being male gender (odds ratioOR=1.934,95% confidence intervalCI:1.484-2.521),with multiple drug use (OR=1.773,95% CI:1.302-2.414),having first sexual behavior at early age (OR=1.791,95% CI:1.426-2.250),with long-term ATS use (OR=1.478,95% CI:1.197-2.826),and with a high impulsivity score (OR=1.382,95% CI:1.120-2.707)were more likely to have high risk sexual activity.Conclusion The influence factors of high-risk sexual behavior are relatively complex among amphetamine-type stimulant addicts,suggesting specific intervention strategies should be developed to reduce high-risk sexual activities among the population.