Abstract: Objective To explore influencing factors of prognosis for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients after radical resection and to provide references for improving life quality of the patients.Methods We enrolled 426 HCC patients with radical resection from December 2003 through 2012 and conducted telephone follow-up every 2-4 months to collect relevant information.R 3.1.2 was used in univariate and multivariate Cox regression to analyze the influencing factors of survival among the patients.Results The mean survival time of the patient was 42.06±26.75 months and the 1-,2-,3-,4-,and 5-year survival rate were 86.15%,73.71%,66.67%,61.27%,and 58.92% among the patients,respectively.Multivariate Cox regression analysis showed that the risk factors of the survival of the patients included vascular invasion,with a B Child-Pugh grade,α-fetoprotein (AFP) >400 ng/mL,high expression of topoisomerase Ⅱα (TopoⅡα),and alcohol consumption,while the protective factors included tumor encapsulation and Edmonson grade I.Conclusion Vascular invasion,Child-Pugh grade,AFP,TopoⅡα expression,alcohol consumption,tumor encapsulation,Edmonson grade could affect the prognosis of HBV-related HCC patients after radical resection.