Abstract: The aim of this study was to examine whether cytochrome P450 2E1(CYP2E1)and/or glutathione S-transferase M1(GSTM1)genetic polymorphisms were related to suseptibility to gastric cancer.Genotyping of CYP2E1 and GSTM1 was performed using the polymerase chain reaction on peripheral white blood cell DNA from 91 patients with gastric cancer and 94 controls in a case control study.The results showed that GSTM1-null genotype significantly increased the risk of developing risk of gastric cancer.Persons who carrided the C1/C2 genotpes of CYP2E1 and GSTM1-null had a higher risk of gastric cancer than those with the C1/C1 and GSTM1-nonull genotype,(OR=4 58,85%CI=1 54-14 11).The odds ratio of developing gastric cancer for smoking exposure was strikingly increased in individuals carried the C1/C2 or C2/C2 genotype of CYP2E1 and GSTM1 null(OR=20 00,5%CI=3 69-131 61).These results suggested that CYP2E1 and GSTM1 polymophisms are likely to be associated with gastric cancer susceptibility.