Abstract: Cost benenfit and effectiveness analysis of type iv inactivated vaccine againsthemorrhagic fever with renal syndrome was conducted and it was guildline for strategy of immunizing-with type iv inactiveated vaccine against HFRS.Based on materials of epide-milogy efficacy of type iv inactivated vaccines against HFRS in Jiande county.Benefit-cost ratio (BCR) and Cosi-effective ratio (CER) were estimated for 5 cohorts of different age groups.BCR and CER of all age groups were under 1 and above respectively.CER of 30~39 age group (11080.82 yuan REM) was almost to the average pecapital GDP(10800 yuan) and CER of other age groups was larger.Sensitivity analysis showed that vaccine cost,protect rate and protect period of vaccine affected CER and BCR more.CER of 20~29,30~39 and 40~49 age groups with high risk were under GDP.It couldn’t obtain benefit of inactivatedvac-cines inoculated against HFRS;The first people immunlized with inactivated vaccine against HFRS was 30~39 age group and the next peoples were 40~49 age and 20~29 age group;Vaccine can be used to cover the population of high risk of age 15~59 years old,but the key population of vaccine gived was 20~49 age groups.