Distribution characteristics and epidemiological significance of hepatitis B marker serological model in health examinees of Zhejiang province

Objective To study hepatitis B marker distribution model in the people receiving health examination. Methods The hepatitis B markers(HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc)and liver function were detected in 21 035 people receiving health examination. Results The positive rate of HBsAg for positive model was 7.21% (1 517/21 035).The positive rate of anti-HBs was 42.05%and the positive rate for hepatitis B virus-marker(HBV-M) negative model was 42.17%.The HBsAg,anti-HBc,and anti-HBe positive rates in the male were higher than those in the female(P<0.01).The anti-HBs,anti-HBc,anti-HBe,and anti-HBc positive rates in the female were significantly higher than those in the male(P<0.01).HBsAg,HBeAg and anti-HBc positive rates were decreased with age in the male and female(P<0.01)and the anti-HBc positive rate was increased with the increment of age(P<0.01).The level of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the HBsAg positive model group were higher than those in HBV-M negative model group(P<0.01). Conclusion The positive rate of HBsAg was 7.21%in health examinees in Zhejiang province and the HBsAg positive model was the major model of abnormal liver function.The ability of eliminating HBV in the female was better than that in the male.The main model of HBV-M was anti-HBs positive and HBV-M negative model.The vaccination for HBV should be promoted for the HBV-M negative model to control HBV infection.