Risk factors associated with fatality among severe cases of pandemic influenza H1N1 in Nanchang city

Objective To explore the risk factors associated with fatality among severe cases of pandemic influenza H1N1 in Nanchang city.Methods A case-control study was conducted with 9 cases of death and 66 severe cases of influenza H1N1 as controls.Results The ratio of the severe cases was 8.33% among all influenza A H1N1 patients.The mortality was 1%.The fatality of the cases with chronic liver disease,pregnancy,and invasive oxygen treatment was higher than that of severe cases with the odds ratio(OR)(95% confidence intervalCI)of 25.6(1.97-333.55),12.67(0.86186.91),and 10(1.07-93.44).Compared with the cases without complication,the fatality of the cases with 2 or 3 complications was higher with the OR(95% CI)of 9.83(1.17-82.94)and 118(8.72-1597).Conclusion The basic diseases (chronic liver disease,cardiovascular disease,pregnancy),with invasive oxygen treatment and complications are risk factors of fatallty for serere influenza A H1N1 patients.The case with the risk factors should be diagnosed earlier,monitored closely,and treated properly to reduce the fatality.