Impacts of simultaneous vaccination of pneumococcal conjugate vaccine and other routine vaccines on immunogenicity and safety of the vaccines

Infancy is an important period for the implementation of planned immunization and various vaccines should be administered during this period. In order to make the immune process more convenient, several vaccines may be administered concomitantly under the condition of no interference on immunogenicity and safety. Pneumococcal conjugate vaccines (PCVs), which is effective for the prevention of Pneumococcus-related diseases, has been globally applied among children. The study systematically reviewed published literatures on immunogenicity and safety when PCVs administered concomitantly with other routine pediatric vaccinations, and analyzed their interactions of co-administration. Based on the analyses, few impacts on the immunogenicity of both PCVs and other routine pediatric vaccines were observed when PCVs were administered concomitantly with vaccines against pertussis, tetanus, diphtheria, measles, mumps, rubella, varicella, polio, hepatitis A, hepatitis B, Meningococcus serogroup C, meningococcal ACWY, Haemophilus influenzae type b, and expressed acceptable safety profiles. The results of the study suggest that PCVs could be administered concomitantly with other routine pediatric vaccines so as to reduce the frequency of vaccinations and improve the efficiency of planned immunization under acceptable immunogenicity and safety profiles.