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Volume 36 Issue 10
Sep.  2020
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XIE Chao-mei, QIN Ping, ZENG Xi-peng, . Dynamic changes of IgM and IgG in confirmed COVID-19 cases: detection results analysis[J]. Chinese Journal of Public Health, 2020, 36(10): 1396-1398. doi: 10.11847/zgggws1130146
Citation: XIE Chao-mei, QIN Ping, ZENG Xi-peng, . Dynamic changes of IgM and IgG in confirmed COVID-19 cases: detection results analysis[J]. Chinese Journal of Public Health, 2020, 36(10): 1396-1398. doi: 10.11847/zgggws1130146

Dynamic changes of IgM and IgG in confirmed COVID-19 cases: detection results analysis

doi: 10.11847/zgggws1130146
  • Received Date: 2020-04-26
    Available Online: 2020-08-21
  • Publish Date: 2020-10-15
  •   Objective  To analyze dynamic changes of immunoglobulin M (IgM) and immunoglobulin G (IgG) in 49 confirmed cases of coronavirus disease 2019 (COVID-19) during various periods of the disease and to explore regulations and characteristics of antibodies production against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for providing evidences for effective prevention and control of COVID-19 epidemic.  Methods  Totally 114 blood samples were collected from 49 viral nucleic acid detection-confirmed COVID-19 patients (one sample for 17 cases and 2 – 7 samples for 32 cases) and blood samples from another 49 viral nucleic acid negative cases were also collected as controls in Changde city, Hunan province between January 24 and February 22, 2020. Fluorescent immunochromatography was used to detect serum SARS-CoV-2 IgM and IgG and dynamic changes in IgM and IgG were statistically analyzed.   Results  Of the 114 serum specimens from 49 viral nucleic acid positive cases, 96 (84.21%) were IgM positive and 108 (94.74%) were IgG positive, with a significant difference between the two positive rates (P < 0.05). The titer of IgG antibody was significantly higher than that of IgM (P < 0.05) and the titer of IgM was significantly different in the cases at various periods of the disease. The positive rate of IgG varied significantly among the patients at different periods of the disease (P < 0.05). In addition, the results of repeated detection demonstrated that there was a close positive correlation of positive conversion period of IgM and IgG with negative conversion period of viral nucleic acid.   Conclusion  The detection of IgM and IgG is an effective supplement to the nucleic acid tesing for COVID-19. The dynamic monitoring of SARS-CoV-2 IgM and IgG antibody are of significance for COVID-19-related epidemiological survey, therapeutic effect evaluation, and vaccine development.
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  • [1]
    Zhu N, Zhang DY, Wang WL, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. The New England Journal of Medicine, 2020, 382(8): 1 – 7. doi: 10.1056/NEJMoa2001017
    [2]
    国家卫生健康委办公厅, 国家中医药管理局办公室. 关于印发新型冠状病毒肺炎诊疗方案(试行第七版)的通知(国卫办医函〔2020〕184号)[EB/OL]. (2020 – 03 – 03). http://www.nhc.gov.cn/xcs/zhengcwj/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml.
    [3]
    Huang CL, Wang YM, Li XW, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. The Lancet, 2020, 395(10223): 497 – 506. doi: 10.1016/S0140-6736(20)30183-5
    [4]
    国家卫生健康委办公厅. 新型冠状病毒肺炎防控方案(第五版)[EB/OL]. (2020 – 02 – 21). http://www.gov.cn/zhengce/2020 – 02/22/content_5482011.htm.
    [5]
    罗效梅, 王静, 张娅, 等. 全血SARS-CoV-2特异性抗体检测对2019-冠状病毒病的临床应用价值分析[J]. 西南大学学报(自然科学版), 2020, 43(3): 30 – 34.
    [6]
    唐鹏, 赵自武, 刘颖娟, 等. 化学发光和胶体金法检测新型冠状病毒特异性抗体比较及其临床意义[J]. 武汉大学学报(医学版), 2020, 41(4): 517 – 520. doi: 10.14188/j.1671-8852.2020.0131
    [7]
    邹明园, 吴国球. 抗原交叉反应对新型冠状病毒血清特异性抗体检测的影响[J]. 临床检验杂志, 2020, 38(3): 161 – 163.
    [8]
    吴满辉, 周莉莉, 林小鸿, 等. SARS患者康复后血清抗SARS病毒特异性抗体IgM和IgG动态变化[J]. 岭南急诊医学杂志, 2009, 14(1): 10 – 12. doi: 10.3969/j.issn.1671-301X.2009.01.004
    [9]
    闫惠平, 檀玉芬, 庄辉, 等. 严重急性呼吸综合征患者冠状病毒总抗体及N和S蛋白抗体的随访研究[J]. 中华内科杂志, 2006, 45(11): 896 – 899. doi: 10.3760/j.issn:0578-1426.2006.11.006
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    • Receive:  2020-04-26
    • Online:  2020-08-21
    • Published:  2020-10-15

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