Advance Search
Volume 39 Issue 1
Jan.  2023
Turn off MathJax
Article Contents
WANG Mei, YAN Jun, ZHANG Chen-yang, . Stability of cadmium-induced renal injury biomarkers in adult residents with long-term environmental cadmium exposure: a 13-month follow up survey[J]. Chinese Journal of Public Health, 2023, 39(1): 46-49. doi: 10.11847/zgggws1138112
Citation: WANG Mei, YAN Jun, ZHANG Chen-yang, . Stability of cadmium-induced renal injury biomarkers in adult residents with long-term environmental cadmium exposure: a 13-month follow up survey[J]. Chinese Journal of Public Health, 2023, 39(1): 46-49. doi: 10.11847/zgggws1138112

Stability of cadmium-induced renal injury biomarkers in adult residents with long-term environmental cadmium exposure: a 13-month follow up survey

doi: 10.11847/zgggws1138112
  • Received Date: 2022-01-26
    Available Online: 2022-12-19
  • Publish Date: 2023-01-31
  •   Objective  To investigate the stability of cadmium-induced renal injury biomarkers in community adults with low environmental exposure.   Methods  The participants of the survey were 80 permanent residents aged 40 – 69 years living in local areas at least 10 years (63 in an area with relatively heavy environmental cadmium pollution and 17 in an area with similar social and economic development to those of the contaminated area but with low environmental cadmium pollution) in Gansu province. Peripheral blood and morning urine samples of the participants were collected three times in November 2019, November 2020 and December 2020, for detections of blood cadmium, urinary cadmium, urinary β2-microglobulin (Uβ2-MG), urinary N-acetyl-β-D-glucosaminidase (UNAG), urinary retinol binding protein (URBP), urinary metallothionein (UMT) and urinary micro-albumin (UALB), respectively. Relevant information of the participants were collected simultaneously with questionnaire interviews. Descriptive statistics with variance analysis and Chi-square test were performed on the data collected.   Results  The main effects of time on blood cadmium, UALB, UMT and URBP were not statistically significant (all P > 0.05). The main effects of time on urinary cadmium, UNAG and Uβ2-MG were statistically significant (all P < 0.001). Pairwise comparison showed that there were no significant differences in blood cadmium, UALB, UMT and URBP levels among detections at the three time points (all P > 0.05); but the levels of urinary cadmium in the second and third detection were significantly higher than that in the first detection (both P < 0.001); the level of urinary cadmium in the third detection was significantly higher than that in the second detection (P < 0.01); the UNAG level of the second detection was significantly higher than that of the first detection and the third detection (both P < 0.001). There was no significant difference in UNAG level between the first test and the third test (P > 0.05). The Uβ2-MG level in the third detection was significantly higher than that in the first and the second detection (both P < 0.001). There was no significant difference in Uβ2-MG level between the first and second detection (P > 0.05).   Conclusion  Blood cadmium, UALB, UMT and URBP are less affected by time effect and of good stability; while urine cadmium, UNAG and Uβ2-MG are more affected by time effect and of poor stability.
  • loading
  • [1]
    Sherief LM, Abdelkhalek ER, Gharieb AF, et al. Cadmium status among pediatric cancer patients in Egypt[J]. Medicine, 2015, 94(20): e740. doi: 10.1097/MD.0000000000000740
    [2]
    韩致超, 康辉, 张真, 等. 环境镉暴露与相关肾功能改变及尿转化生长因子 – β1的关系[J]. 环境与职业医学, 2021, 38(3): 210 – 216.
    [3]
    龚频, 白晓换, 陈福欣, 等. 镉的肝脏毒性研究进展[J]. 工业卫生与职业病, 2016, 42(4): 318 – 320.
    [4]
    邱诗宝, 褚佳, 汤昌海, 等. 江西省非镉作业人群尿镉水平的研究[J]. 江西医药, 2020, 55(7): 936 – 939. doi: 10.3969/j.issn.1006-2238.2020.07.047
    [5]
    张蕴蕊, 梁旭霞, 陈文才, 等. 长期镉暴露人群肾损伤效应的流行病学调查[J]. 中华预防医学杂志, 2015, 49(7): 638 – 643. doi: 10.3760/cma.j.issn.0253-9624.2015.07.012
    [6]
    蔡嘉旖, 张文丽. 人群暴露环境镉污染与健康危害的流行病学研究进展[J]. 环境卫生学杂志, 2019, 9(6): 621 – 627.
    [7]
    康辉, 雷立健, 郭建勇, 等. 低剂量环境镉暴露人群肾功能状况与血浆转化生长因子-β1的关系[J]. 环境与职业医学, 2018, 35(3): 196 – 202.
    [8]
    杨杏芬, 吴永宁. 镉对人群健康效应研究需要注重肾损害水平之下的低剂量暴露[J]. 中华预防医学杂志, 2016, 50(4): 292 – 295. doi: 10.3760/cma.j.issn.0253-9624.2016.04.002
    [9]
    Akesson A, Lundh T, Vahter M, et al. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure[J]. Environmental Health Perspectives, 2005, 113(11): 1627 – 1631. doi: 10.1289/ehp.8033
    [10]
    Satarug S, Moore MR. Adverse health effects of chronic exposure to low - level cadmium in foodstuffs and cigarette smoke[J]. Environ-mental Health Perspectives, 2004, 112(10): 1099 – 1103. doi: 10.1289/ehp.6751
    [11]
    蒋梦珂, 陈琦, 丁震, 等. 探索尿镉作为人群镉暴露生物标志物的影响因素[J]. 环境与职业医学, 2021, 38(10): 1057 – 1062.
    [12]
    Chaumont A, Voisin C, Deumer G, et al. Associations of urinary cadmium with age and urinary proteins: further evidence of physiological variations unrelated to metal accumulation and toxicity[J]. Environmental Health Perspectives, 2013, 121(9): 1047 – 1053. doi: 10.1289/ehp.1306607
    [13]
    刘杨. 低尿镉水平暴露与中国普通人群肾脏功能损伤的关联性研究[D]. 武汉: 华中科技大学, 2020.
    [14]
    冯雪芳, 王雅楠, 韩琳, 等. 社区人群镉蓄积与清蛋白尿的相关性研究[J]. 中国全科医学, 2017, 20(S3): 96 – 97.
    [15]
    Liu J, Liu YP, Habeebu SM, et al. Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein - I/II null mice[J]. Toxicology, 2000, 147(3): 157 – 166. doi: 10.1016/S0300-483X(00)00194-3
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Article views (263) PDF downloads(33) Cited by()
    Proportional views
    Publishing history
    • Receive:  2022-01-26
    • Online:  2022-12-19
    • Published:  2023-01-31

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return