The Primary Study of Antagonism of Selenium on Fluoride Induced Reproductive Toxicity of Male Rat

The protective effect of ascorbic acid at dose level of 1.0mg/L in drinking water against the fluoride-induced damage on reproductive system of rat was studied.150mg/L sodium fluorid(NaF)in drinking water of male rat can cause the significant decrease of sperm count and mobility,the increase of serum and testicular lipid peroxides(LPO)contents,and the adenosine triphosphatase(ATPase)activity depression of epididymis.All of those effects are reversible by adding adequate ascorbic acid in drinking water simultaneously.The effects of ascorbic acid against fluorideinduced damages are similar to those produced by 2.0mg/LNa₂SeO₃ in the drinking water of rats.However,no significant recovery of fluoride-induced effects on GSH2Px activities in the tissues of testis and epididymis were observed in ascorbic acid and fluoride group.The mechanism of ascorbic acid on fluoride-induced damage of male reproducttve system need to be further studied.