Studies on In Vitro Inhibitory Effects of Folic Acid On Human Hepatic Cancer Cell Line

ObjectiveTo study the antitumor activities of folic acid,Folic acid are dealed with human hepatic cancer cell line SMMC-7721 in vitro.MethodsBy means of there approaches as follows:cell proliferation curve analysis,M TT assay and cell cycle analysis by FCM.ResultsThat after treatment with 13.5×10^-5 mol/L,40.5×10^-5 mol/L folic acid selectively inhibited the activity and function of SMMC-7721.There were apoptotic peaks in cell cycle analysis by FCM and apoptosis rate reached 27.1%.ConclusionThe effects of folic acid on human umbilical vein end othelial cells were slightly.