The Relationship between Apoptosis and bcl-2 Gene in Primary Hepatocarcinoma

Objective To study the relationship between apoptosis and apoptosis-related gene bcl-2.Methods Using terminal deoxynuleotidyl transferase mediated dUTP biotin nick end labeling(Tunel)and immunohisto chemistry SP method,the apoptosis rate and the expression of bcl-2 in HCC was examined.Results The apoptosis rate was significantly higher in chronic hepatitis than in HCC(P<0.01).The frequency of expression of bcl-2 in HCC was 51.3%,while that in chronic hepatitis was 25%.The expression of bcl-2 was negatively correlated with the apoptosis(P<0.01).Conclusion Apoptosis is inhibited in HCC which may be related to bcl-2 gene dysregulation.