Survey and Analysis on HBV and HCV Infection of Families of HCC

Objective In order to investigate infection status about HBV and HCV in family members of HCC and to reveal the opportunity exposed to HBV and HCV infection.Methods HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc,anti-HCV were detected in the sera of family members from case and control using ELISA,and HBV DNA with PCR.Results HBsAg,anti-HBe,anti-HBc and HBV total infection ratio were higher in the children of case group than that in control;anti-HBc and HBV total infection ratio in the spouse of case group were also higher than that in control.Statistical variations were significant(P<0.05 or P<0.01).The examination of HBVDN A in the children of case group was higher than that in control(P<0.05).There was a close connection between HBeAg and HBV DNA.Positive HBV DNA were with positive sera of HBeAg.There was no statistical variation between case and control in anti-HCV(P>0.05).HBsAg and anti-HBc were led into conditional logistic regression equation with odds ratio value of 27.96,4.77 respectively.Conclusion There was a trend of clustering of HBV infection in families of HCC.HBsAg and anti-HBc were representitive mar kers in Hepatitis B virus infection in the family members of HCC.Close living contact was also one of the routes of transmission.HCV infection wasn't the major type of infection.