Study on Toxicity of Methyl Tertiary-butyl Ether Unlead Gasoline(MTBE UG)

Objective To evaluate basic toxicities of MTB EUG and to look for valuable indicators on health surveillance.Methods The acute toxicities were conducted with mice,rats and rabbites,through oral,inhalation and dermal contaminations.The accumulative toxicity and subchronic toxicity test were also studied in the meantime.Results LD₅₀ of rats and mice were 15 730 and 15 860mg/kg·bw respectively,while LC₅₀ were 123 500 and 114 380mg/m³ respectively.The accumulation coefficient(Kcum)is greater than 5LC₅₀.In subchronic toxicity test,no significant differences were observed in several indexes of blood routine.Only ALT in 12 biochemical indicators increased in the high dose and medium dose groups.The immunoglobulin A(IgA)in three exposure to MTB EUG groups were lower than that in gasoline and control groups.The mean weights of liver and kidney were significantly different between exposed rats and unexposed rats.Pathological examinations showed thathyalinosis of hepatic cell,epithelial cell degeneration and protein cast of proximal convoluted tubule were induced by MTB EUG.Conclusions MTB EUG belonged to a lower toxicity and slightly accumulative substance.Ithad damage effects on animal's liver,kidney and immunity function up to a point.