Study on Quantitative Method and Immune Regulation of Ig/Ig two-component-Determined Circulating Immune Complexes

Objective To establish a quantitative method to Ig/Ig two-componen-tdetermined circulating imune complexes(Ig/Ig-TCIC)and study whether Ig/Ig-TCIC was related to the function of immune regulation.Methods Quantity of Ig/Ig-TCIC was carried out by the combination of Ig immune biology with mathematics.The immune reg ulation of Ig/Ig-TCIC was characterized by the correlation of Ig/Ig-TCIC with C3/Ig-TCIC,serum Ig and C3,and complexed Ig and C3.Results The quantitative method was established and significant regularity was found from the association of Ig/Ig-TCIC with these humoral immune markers.Conclusion This quantitative method was simple and useful.Ig/Ig-TCIC plays an important role in immune regulation as a middle product of immune network.