Genetic Polymorphism of Glutathione S-transferase P1 Gene and Susceptibility to Lung Cancer

Objective To analyse the relationship between the GSTP1 genotypes and susceptibility to lung cancer,and explore the sensitive genotype of lung neoplasm through evaluating on the intension of the association between GSTP1 gene and lung cancer and to provide basis for screen and diagnosis of lung cancer.Methods The molecular epidemiological studies was adopted.A case-control study was carried out,with 158 cases and 168 controls;Polymerase Chain Reaction-Restriction Fragment Length Polymorphism(PCR-RFLP)was taken to analyse the GSTP1 genotypes and identify the gene frequencies.Results The difference of GSTP1 genotypes distribution were not statistically significant between cases and controls.After excluding the confounding of smoking in the elder age subgroup(age 50 years or elder),the frequencies of GSTP1 variant genotypes(AG or GG)in the cases were evidently higher than that in the controls.Conclusion In the elder age subgroup(age 50 years or elder),the risk to lung cancer was 8.3 times higher among the males carrying G alleles(AG and GG)and than those carrying A alleles(AA)with the exception of smoking.