Effects of Lead on Changes of NO.NOS in Rat Kidney

Objective To study the effect of chronic lead exposure on the changes of nitric oxide synthase(NOS)activity and nitric oxide(NO)content in kidney.Methods Wistar rats were exposed to lead from drinking 0,18.4 and 184mg/L lead acetate solution.Results Compared with control group,kidney NOS activity in high-dose lead exposed groups was significantly decreased after 30 days exposure(P<0.05).NOS activity in low-dose lead exposure groups increased,but show no significant differ ence(P>0.05).NO content in kidney were markedly decreased after 90 days exposure in low-dose group and 60 days in high-dose group(P<0.05).Conclusion NOS activity and NO content in kidney were significantly decreased during chronic lead exposure.The decrease of NOS activity and NO content resulted from lead exposure may be correlated with the neural poisoning of kidney.