Effects of Oral Administration of Aluminum Potassium Sulfate on Liver and Kidney of Rabbits

Objective To investigate the effects of different aluminum(Al)levels on liver and kidney of rabbits.Methods Belgium rabbits were administered with aluminum potassium sulfate successively for eight weeks,and the contents of trace elements Copper(Cu),Zinc(Zn),Manganese(Mn)were analyzed.Also,both superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in liver and kidney were examined.The pathological examination was observed.Results The Al levels in liver and kidney remarkably increased with increase of aluminum potassium sulfate intake(P<0.001),and the Cu,Zn,Mn levels decreased in different degrees(P<0.05,P<0.01).The SOD activities of liver and kidney significantly decreased in high dose group(P<0.05,P<0.01).The GSH-Px activities of liver and kidney were inhibited in both low and high dose group.The liver and kidney damage was found among aluminum-loaded rabbits in pathological examination,and the extent relied on dosage.Conclusion Aluminum inhibited SOD and GSH-Px activities by decreasing Cu,Zn,Mn levels in liver and kidney of rabbits may constitute one of the factors for the mechanism of tissue injury by alnminum.