Effects of Selenium on Oxygen Free Radical Induced Injury of Rat Cerebral Mitochondria

Objective The effects of selenium on oxygen free radical inducing injury of rat cerebral mitochondria were investigated.Methods The oxygen free radicals(OFRs)injured cerebral mitochondria induced by Fe²⁺-Cys in vitro were exposed to 5.0×10^-5-5.0 mol/L.Na₂SeO₃ and the changes of injured mitochondria swelling,membrane fluidity,MDA levels and mitochondria structures were observed.Results Low Se concentration(5.0×10^-4-5.0×10^-2 mol/L)can inhabit the injury of rat cerebral mitochondria induced by oxygen free radicals while high Se concentration(0.5-5.0 mol/L) cause toxicity and both are with a relationship of dose-dependent response.Conclusion Low Se concentration is helpful to delay aging and against nervous disease.