Study on Antiproliferation Effects of Genistein in Vitro

ObjectiveTo elucidate the effects of genistein on cancer or normal cell.MethodsThe inhibitory effects of genistein on the proliferation of human gatric cancer cell line SGC-7901,human lung cancer line YTMLC-90,Chinese hamster ovary cell line CHO and peripheral blood lymphocyte from healthy person were studied.ResultsThere are significantly inhibitory effects of genistein on proliferation of SGC-7901,YTMLC-90 and CHO cell line with a dose-effect and time-effect relationship.The lowest inhibitary concentration of genistein is 18.5μmol/L.Genistein affected the normal peripheral blood lymphocyte with a very slight extent.ConclusionGenistein inhibits the growth of tumor cells,so that it may have important significance in the treatment and prevention of cancer as a effective ingredient of health food.However,it is also found in this study that genistein was toxic to CHO cell line,and a further study is needed for the comphrehensive evalua2 tion of biological activities of genistein.