Analysis on Polymorphism of SDF1, CCR2b, CCR5 Related to HIV-1 Infection of Chinese HIV-1 Infected Population

ObjectiveTo analyse the frequency and polymorphism of HIV-1 resistant SDF1,CCR 2b,CCR5 alleles in 91 HIV-1 infected Chinese persons.MethodsPCR/RFLP assay technology and DNA sequencing were used to analyse gene poly mor phism of SDF 1,CCR2b,CCR5 among HIV-1 infected population.ResultsccR5△32 gentype was not found in 91 HIV-1 infected Chinese persons.The frequencies of SDF1-3cA and CCR2b-64I alleles were 26.40% and 21.43%.DNA sequencing had the same results with PCR/RFLP.ConclusionThese 91 HIV-1 infected Chinese persons were all HIV genetic susceptive person.The frequencies and polymorphism of HIV-1 resistant SDF 1,CCR2b,CCR5 alleles in Chinese HIV-1 infected population were analyzed,which can help further study how SDF1,CCR2b and CCR5 gene polymorphism affected the course of AIDS of Chinese population.