Case-merely Study on Psoriasis Vulgaris

Objective To study the HLA-DQA₁ *0104,DQA₁ *0201,DQA₁ *0501 alleles and environmental factors interaction in psoriasis vulgaris.Methods Using case-merely study,176 psoriatics were investigated.The HLA-DQA₁ *0104,DQA₁*0201 and DQA₁*0501 alleles were examined by PCR-SSP.Results (1)The HLA-DQA₁*0104 allele and stress were interaction in psoriasis(P=01038 3,OR=0141).(2)The HLA-DQA₁*0201 allele,drinking(P=0.045 1,OR=0.52)or operation(P=0.033 2,OR=3.93)were interaction in psoriasis.(3)The HLA-DQA₁*0501 allele and vaccination(P=0.014 5,OR=12.0)were interaction in psoriasis.Conclusion The HLA-DQA₁*0104,DQA₁*0201 and DQA₁*0501 alleles improved or reduced risk possibility of environmental factors in psoriasis.