Poisonous effect of 2-methel-4-chlorophenoxyacetic acid in mice

  Objective   To observe the interferring effect of 2-methyl-4-chlorophenox yacetic acid(MCPA)in mice.

  Methods   Three treated groups are divided by three dosage of MCPA(20, 100, 200 mg/kg, P.O).The weight, T ₄, TSH, cholesterol, the coefficient of spleen are analyzed.

  Results   After 17 days, the weight of every treat group are significantly lower than the control groups in the male mice, and the weight decreases with the increasing of the doses in the female mice.Among high-or(and)middle-dose group, TSH in blood and coefficient of spleen are significantly lower, but the content of cholesterol in blood increases compared with other treated gropus and control group.The content of T ₄ in blood is abnormal significantly among low, high-dose groups.

  Conclusion   MCPA can result in obstruction of mice growing, interruption of endocrine, the wither of spleen.The changes of every indexin female is more sensitive than male.