Study on replication status of HBsAg positive pregnant women and newborns

  Objective   In order to explore the replication status of PBMC HBV of HBsAg positive pregnant women and their newborns.

  Methods   151 pregnant women and 153 newborns were collected between 2001 June and 2002 December in Infectious Hospital of Taiyuan city. PBMC HBV DNA were deter mined by selected poly merase chain reaction (sPCR).

  Results   15(9.93%) out of 151 HBsAg positive pregnant women had HBV cccDNA in their PBMC, 7(4.58%) out of 153 newborns had HBV cccDNA in their PBMC, 55(36.42%) out of 151 HBsAg positive pregnant women had HBV rcDNA in their PBMC, 35(22.88%) out of 153 new borns had HBV rcDNA in their PBMC.

  Conclusion   PBMC was the replication site of HBV out of liver. PBMC HBV replicatlon of newborns was related to the replication of their mothers.