Effect of conjugated linoleic acids on leptin level of adipose tissue in obese rats

  Objective   To observe the effect of conjugated linoleic acids(CLA)on body weight, Serum lipids level, leptin expression level in obesity rats, and to discuss the mechanism of CLA effect on fat metabolize.

  Methods   50 female Wistar rats were divided intofive groups(normal control group, fourobesity model groups).The four group rats were fed with high fat and glucose diets fora month, and body weight > 230g 28 rats were divided intofour groups(obesity control group, three conjugated linoleic acids groups), and rats were given different conjugated linoleic acids for four weeks later.Body weight, serum lipids level, lpetin expression level were measured.

  Results   Obesity control group, body weight, serum lipids decreased significantly and leptin expression level in adipose tissue were dicreased.

  Conclusion   Conjugated linoleic acids can reduce Body weight, serum lipids level, and the mechanism maybe through intermediation leptin expression level in adipose tissue.