Study on C667T gene polymorphism and susceptibility to gastric cancer

  Objective   To study the association between genetic polymorphisms of MTHFRC677T and susceptibility to gastric cardia/non cardia cancer, and to investigate the interaction of gene and intake of folates and alcohol drinking in etiology of these cancers in Fujian population.

  Methods   The case control study with the same control group was conducted.The gene types were investigated by PCR-RFLP.

  Results   The variated genotype(CT or TT)of MTHFR increased the risk of non-cardia gastric cancer after adjusting for potential confounders.There were interactions between variated genotype and low intake of fresh vegetables, fresh fruits and high drinking of alcohol in cardia cancer group.While the interactions between variated genotype and low intake of pean products, fresh fruits were observed in non-cardia gastric cancer group.

  Conclusion   The synergies between MTHFR variated genotype and low level of folates intake, high alcohol drinking increase the risk of cardia cancer.The variated genotype is a risk factor of non-cardia gastric cancer.The synergies between genotype and low level of folates intake increase the risk of non-cardia gastric cancer.There maybe different risk factors between cardia and non-cardia gastric cancer.